Pesticides / Biocides
Quality Assurance System: Good Laboratory Practice (GLP)
Analytical methods
- Determination of content of active substance (SANCO/3030/99 rev. 4)
- Analytical method validation (SANCO/3030/99 rev. 4)
- Five batch analysis (SANCO/3030/99 rev. 4)
Physico-chemical tests
- Spectral data (MS, NMR, IR, UV/VIS)
- State of substance (20 °C and 101.3 kPa)
- Melting/freezing point (EU A.1/OECD 102)
- Boiling point (EU A.2/OECD 103)
- Relative density (EU A.3/OECD 109)
- Vapour pressure (EU A.4/OECD 104)
- Water solubility (EU A.6/OECD 105)
- Partition coefficient n-octanol/water (EU A.8/OECD 107 + OECD 117)
- Flash point (EU A.9)
- Surface tension (EU A.5/OECD 115)
- Explosive properties (EU A.14)
- Oxidizing properties (EU A.17)
- Solubility in organic solvents (CIPAC MT 181)
- Dissociation constant (OECD 112)
- Viscosity (EN ISO 3140) and other…
Toxicological studies
- Acute oral toxicity - fixed dose procedure (EU B.1bis/OECD 420)
- Acute oral toxicity - acute toxic class method (EU B.1tris/OECD 423)
- Acute toxicity (dermal; EU B.3/OECD 402)
- In vitro skin corrosion: human skin model test (EU B.40/OECD 431)
- In vitro skin irritation (EU B.46/OECD 439)
- Acute toxicity: dermal irritation/corrosion (EU B.4/OECD 404)
- Bovine corneal opacity and permeability test method for identifying ocular corrosives and severe irritants (EU B.47/OECD 437)
- Acute toxicity: eye irritation/corrosion (EU B.5/OECD 405)
- Local lymph node assay (EU B.42 or OECD 429)
- Guinea pig maximisation test (EU B.6/OECD 406)
- Toxicokinetics (EU B.36 or OECD 417)
- Repeated dose (28-days) toxicity (oral; EU B.7 or OECD 407)
- Sub-chronic oral toxicity test (repeated dose 90-days oral toxicity study in rodents; EU B.26/OECD 408)
- Chronic toxicity test (EU B.30/OECD 452)
- Combined chronic toxicity/carcinogenicity studies (EU B.33/OECD 453)
- Reverse mutation test using bacteria (EU B.13/14/OECD 471)
- In vitro mammalian cell micronucleus test (OECD 487)
- In vitro mammalian chromosome aberration test (EU B.10/OECD 473)
- In vitro mammalian cell gene mutation test (EU B.17/OECD 476)
- In vivo mammalian erythrocyte micronucleus test (EU B.12/OECD 474)
- Prenatal developmental toxicity study (EU B.31/OECD 414)
- Two-generation reproduction toxicity test (EU B.35/OECD 416)
- Acute toxicity for fish (EU C.1/OECD 203)
- Daphnia magna, acute immobilisation test (EU C.2/OECD 202)
- Algal inhibition test (EU C.3/OECD 201)
- Activated sludge respiration inhibition test (EU C.11/OECD 209) Daphnia magna reproduction test (EU C.20/OECD 211)
Fate and behaviour in the environment
- Hydrolysis as a function of pH (EU C.7)
- Estimation of the adsorption coefficient (KOC) on soil and on sewage sludge using HPLC (EU C.19/OECD 121)
- Ready biodegradability - DOC die-away test (EU C.4-A/OECD 301A)
- Ready biodegradability - Closed bottle test (EU C.4-E/OECD 301D)
- Biodegradation - Zahn-Wellens test (EU C.9/OECD 302B)
and other...
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